I am a geneticist with broad interests in molecular, population, and evolutionary genetics as applied to human and animal model systems. My work is generally centered on exploring the roles of genetic and epigenetic variation in functional phenotypes. Past projects have involved the analysis of candidate gene, genome-, epigenome- and transcriptome-wide datasets in the context of disease risk/progression and treatment.
Current research in the lab is focused on characterizing and cataloguing antibody genetic diversity among human populations, laboratory mouse strains and rhesus macaques, as well as investigating how genetic variation influences the genomic/molecular regulation of antibody expression and function. Importantly, our ultimate aim is to explore how this information can be leveraged to inform our understanding of disease susceptibility and clinical health outcomes, such as an individual’s personalized response to vaccines or therapeutics. All current projects in the lab involve the application of cutting-edge genomic techniques, including next-generation sequencing and single cell approaches.